Iodine-125

I-125

Half Life: 60.14 days

Radiation: EC, Gamma

Energy:
Gamma: 0.035 Mev (6.5%)
Ka X-rays: 0.027 Mev (112.5%)
KB X-rays: 0.031 Mev (25.4%)

Half-value layer for lead = 0.02 mm

ALI: 20 uCi

DAC: 1E-8 uCi/mL

Hazard: The hazard from I-125 is due to uptake to the thyroid. It is of particular concern when in the form of volatile sodium iodine.
Safety Precautions:
  • Follow General Precautions for working with radioactive material.
  • Use lead foil (~3 mm thick) to shield mCi quantities of I-125.
  • Handle multi-mCi quantities with remote handling tools.
  • Use double gloves when working with volatile NaI.
  • Handle volatile NaI in fume hood.
  • A radioiodine fume hood is available through the Radiation Safety Office.
  • Film badges are required for work with I-125, except when using the I-125 kits. Ring badges are required for work with quantities greater than 1 mCi.
  • Use GM detector or liquid scintillation counter to monitor for I-125.
  • Keep containers of NaI closed when not in use to minimize release of volatile material.
  • A thyroid scan is required within 24 hours, if possible, but not later than 72 hours after working with the following limits or greater:
    • processes in open room or bench with possible escape of iodine from process vessles: a. 1 mCi, if volatile form and
      b. 10 mCi, if bound to nonvolatile agent
    • processes with possible escape of iodine carried out within a fume hood of adequate design, face velocity, and performance reliability:
      a. 10 mCi, if volatile form and
      b. 100 mCi, if bound to nonvolatile agent
    • processes carried out within gloveboxes, ordinarily closed, but with possible release of iodine form processes and occasional exposure to contaminated box and box leakage:
      a. 100 mCi, if volatile form and
      b. 1,000 mCi, if bound to nonvolatile agent
  • Seal all waste containers with NaI to prevent release of volatile material.
  • Dispose of radioactive waste in accordance with requirements in Appendix G of the Radiation Safety Manual.

H-3, C-14, S-35, P-32, I-125, Cr-51, Tc-99m, P-33

Radiation Safety